Cardiac Regeneration
As part of the Institute's O'Brien Department we use human stem cells to engineer beating heart tissue on a lab dish to develop effective and translatable treatments for heart disease.
Lab head: Associate Professor Shiang (Max) LimDeveloping novel biomarker for Friedreich ataxia heart disease
Investigating cardiometabolic disease using human induced pluripotent stem cells
Stem cell-derived human liver organoids for regenerative medicine
Treating cardiac vascular dysfunction in Friedreich ataxia using human iPSC-derived multicellular cardiac organoids
Developing novel therapies for type 2 diabetic heart disease using human iPSC-derived multicellular cardiac organoids
Modelling cardiovascular diseases using human cardiac organoids
Vascular Biology
As part of the Institute's O'Brien Department, our main research focus is generating human blood vessels for integration in various human tissues grown in the laboratory, including human skin and small pieces of human liver (liver organoids). We also study the structure and function of these lab-generated human tissues.
Lab head: Associate Professor Geraldine Mitchell Lab co-head: Dr Kiryu YapLymphatic, Adipose & Regenerative Medicine
As part of the Institute's O'Brien Department, we investigate and seek new treatments for Radiation Injury Bystander Effect (RIBE) in cancer patients and for lipoedema, a condition often misdiagnosed as obesity.
Lab head: Associate Professor Ramin Shayan Lab co-head: Dr Tara Karnezis Professor Marc Achen