We do not know whether JAK inhibitors would increase or decrease the development or impact of T-cell exhaustion and whether these two approaches would make a possible future combination treatment. JAK inhibitors might block the effect of cytokines produced in the islet that we have suggested sustain the reservoir of precursor exhausted T cells in the islets. Or do JAK inhibitors reduce the expression or effect of cytokines like IL-10 that may contribute to the impact of T-cell exhaustion.
This study will utilise the NOD mouse model and our previously produced models of T-cell exhaustion to explore this question.
Supervised by
