This project investigates the genetic causes of chromosome breakage and cancer predisposition using traditional cytogenetic techniques, coupled with advanced CRISPR-based gene editing. During this project you will analyse the effect of loss of function of individual Fanconi anemia (FA) genes in a controlled isogenic background, such as hap1 cells and patient-dervied cells. By focusing on each gene as a unique variable, we aim to unravel the specific genetic mechanisms and severity of chromosome instability. You will develop deeper insights into the mechanisms of cancer biology and rare disease. This study will contribute to a clearer understanding of how genetics impacts genomic integrity and may reveal new avenues for targeted therapies.
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Available for Student Supervision