Michael has been applying an innovative approach to identify new drugs for the hardest-to-treat breast and ovarian cancers. This work has recently provided some intriguing hints about a particular metabolite that may be involved in controlling a cell’s ability to repair damage to its DNA. This is important because new therapies that treat breast and ovarian cancers specifically target DNA repair to kill cancer cells.
This project aims to explore the role of this metabolite in DNA repair.
“Further investigation into how this metabolite interacts with the DNA repair machinery may also inform targeted ways that diet could potentially be used to enhance current cancer treatments,” says Michael.