The work of the Structural Biology Laboratory is internationally recognised. Our work has defined more than 200 crystal structures and more recently, structures derived from cryo-electron microscopy – including those of membrane-associating proteins, detoxifying enzymes and protein kinases. This work has provided insights into cancer, bacterial and viral infections, and neurological diseases such as Alzheimer’s disease.

In recent years, we have emphasised the translational aspects of our work, with increasing focus on structure-based drug discovery. This focus has been underpinned by development of virtual screening and fragment screening platforms in-house, by funding from the Australian Cancer Research Foundation, and partnerships with biotechnology companies including CSL Limited and Janssen.

Current research projects

  • Structural biology of neurodegenerative diseases
    Structural biology of cancer

People

Michael Parker
Michael Parker

Head, Structural Biology

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Emma van der Westhuizen

Lab Manager and Senior Research Officer, Structural Biology Lab

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emma.vanderwesthuizen@svi.edu.au

9231 2492

Available for Student Supervision

Stefan Hermans
Stefan Hermans

Postdoctoral Research Officer, Structural Biology, Neurodegeneration

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shermans@svi.edu.au

+61 3 9231 2519

Available for Student Supervision

Andrew Tsatsanis

Research Officer, Structural Biology

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andrew.tsatsanis@svi.edu.au

Available for Student Supervision

  • Dr Tracy Nero, Research Fellow
  • Gabriela Crespi, Research Assistant
  • Nancy Hancock, Research Assistant
  • Dr Julian Adams, Research and Development Manager, Brookhaven National Laboratory, USA
  • Dr Chris Anstey-Gilbert, CEO, BioEmergence, UK
  • Professor David Ascher, Deputy Director of Biotechnology, University of Queensland
  • Dr Brett Bennetts, Project Manager, The Florey Institute of Neurosciences and Mental Health
  • Dr Sophie Broughton, Senior Program Advisor, Victorian Cancer Agency
  • Dr Brett Cromer, Senior Lecturer, Swinburne University of Technology
  • Dr Urmi Dhagat, Manager, The University of Melbourne
  • Associate Professor Michelle Dunstone, Lab Head, Monash University
  • Dr Guido Hansen, Group Leader, University of Lübeck, Germany
  • Dr Jessica Holien, Research Fellow, RMIT
  • Dr Jack King-Scott, Director, Kings Patent & Trade Mark Attorneys
  • Dr Belinda Michell, Protein Production Specialist, The University of Melbourne
  • Dr Craig Morton, Principal Research Scientist, CSIRO
  • Associate Professor Aaron Oakley, Research Fellow, University of Wollongong
  • Dr Lorien Parker, Owner, SciencePlay Kids
  • Professor Jamie Rossjohn, Head of Infection and Immunity Program, Monash University
  • Dr Peter Walsh, Director, Yarra Trail Medical
  • Dr Jerome Wielens, Director, Health and Life Sciences, Breakthrough Victoria
  • Professor Matthew Wilce, Lab Head, Monash University

Student projects

PhD/Honours

Structural biology of proteins involved in neurodegenerative disorders and mental illness

Lab: Structural Biology

Supervisor(s): Professor Michael Parker

Diseases focus: Healthy Ageing

Selected publications

Parker, M.W., Buckley, J.T., Postma, J.P., Tucker, A.D., Leonard, K., Pattus, F. & Tsernoglou, D. (1994) Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states. Nature 367, 292-295. DOI: 10.1038/367292a0

Rossjohn, J., Feil, S.C., McKinstry, W.J., Tweten, R.K. & Parker, M.W. (1997) Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell 89, 685-692. DOI: 10.1016/s0092-8674(00)80251-2

Rossjohn, J., Cappai, R., Feil, S.C., Henry, A., McKinstry, W.J., Galatis, D., Hesse, L., Multhaup, G., Beyreuther, K., Masters, C.L. & Parker, M.W. (1999) Crystal structure of the N-terminal, growth factor-like domain of Alzheimer’s amyloid precursor protein. Nature Struct. Biol. 6, 327-331. DOI: 10.1038/7562

Hansen, G., Hercus, T.R., McClure, B.J., Stomski, F.C., Dottore, M., Powell, J., Ramshaw, H., Woodcock, J.M., Xu, Y., Guthridge, M., McKinstry, W.J., Lopez, A.F. & Parker, M.W. (2008) The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 134, 496-507. DOI: 10.1016/j.cell.2008.05.053

Miles, L.A., Crespi, G.A.N., Doughty. L. & Parker, M.W. (2013) Bapineuzumab captures the N-terminus of the Alzheimer’s disease amyloid-beta peptide in a helical conformation. Sci. Rep. 3, 1302. DOI:10.1038/srep01302

Miles, L.A., Hermans, S., Crespi, G.A.N., Gooi, J.H., Doughty, L., Nero, T.L., Markulić, J., Ebneth, A., Wroblowski, B., Oehlrich, D., Trabanco, A.A., Rives, M-L., Royaux, I., Hancock, N.C., & Parker, M.W. (2019) Small molecule binding to Alzheimer’s risk factor CD33 promotes Abeta phagocytosis. iScience 19, 110-118. DOI: 10.1016/j.isci.2019.07.023

Related news

Funding supports new approach to Alzheimer’s disease
News

June 2022

Funding supports new approach to Alzheimer’s disease

A team led by SVI’s Professor Michael Parker was recently awarded a Faye Williams Innovation Grant from the Dementia Australia Research Foundation, to support testing of a potential new approach to treating Alzheimer’s disease.

Targeting immune cells to treat Alzheimer’s
News

September 2022

Targeting immune cells to treat Alzheimer’s

In the search for new treatments, Professor Michael Parker and his team at SVI have focused on different ways that the power of specialised immune cells in the brain – called microglia – can be harnessed.